Effect of Recurrent Mossy Fiber Growth Modest Increase in Extracellular Potassium Unmasks
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منابع مشابه
Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.
The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cells in seizures. Despite the presence of robust recurrent mossy fiber growth, orthodromic or antidromic activation of granule cells usually doe...
متن کاملRecurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
A common feature of temporal lobe epilepsy and of animal models of epilepsy is the growth of hippocampal mossy fibers into the dentate molecular layer, where at least some of them innervate granule cells. Because the mossy fibers are axons of granule cells, the recurrent mossy fiber pathway provides monosynaptic excitatory feedback to these neurons that could facilitate seizure discharge. We us...
متن کاملLack of Effect of Mossy Fiber-Released Zinc on Granule Cell GABAA Receptors in the Pilocarpine Model of Epilepsy
Molnár, Péter and J. Victor Nadler. Lack of effect of mossy fiber-released zinc on granule cell GABAA receptors in the pilocarpine model of epilepsy. J Neurophysiol 85: 1932–1940, 2001. The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in the epileptic brain and serves as a mechanism for synchronization of granule cell epileptiform activity. It has been suggested that ...
متن کاملHuman limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission.
PURPOSE Limbic encephalitis (LE) is a central nervous system (CNS) disease characterized by subacute onset of memory loss and epileptic seizures. A well-recognized form of LE is associated with voltage-gated potassium channel complex antibodies (VGKC-Abs) in the patients' sera. We aimed to test the hypothesis that purified immunoglobulin G (IgG) from a VGKC-Ab LE serum would excite hippocampal ...
متن کاملLack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy.
The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in the epileptic brain and serves as a mechanism for synchronization of granule cell epileptiform activity. It has been suggested that this pathway also promotes epileptiform activity by inhibiting GABA(A) receptor function through release of zinc. Hippocampal slices from pilocarpine-treated rats were used to evaluate t...
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